Hundreds of Afghans - some shouting "Death to America" - have held a protest against an anti-Islam film in the eastern city of Jalalabad, The Associated Press reported.

The film depicts the Prophet Muhammad as a fraud, a womanizer and a madman.

Since it surfaced on the Internet, it has prompted violent protests at U.S. embassies in the Middle East. The American ambassador and three other U.S. staff members were killed when the U.S. consulate in Benghazi, Libya was attacked.

It is unclear who organized Friday's demonstration in the Marko area of Nangarhar province between Jalalabad and the Pakistan border.

One protester, a man named Zhirullah who spoke to the AP on the phone from the site, says the crowd called on Afghan President Hamid Karzai to cut relations with the United States.