Experimental Alzheimer's drug improves memory in miceDecember 21, 2018 - 17:29 AMT PanARMENIAN.Net - An experimental drug known as A03, which was previously developed to treat depression, increases the levels of the enzyme Sirtuin1, or SirT1, and improves memory in mice. The mice were genetically modified to have a protein called ApoE4, the most common genetic risk factor for Alzheimer's disease in humans that has been linked to some forms of the disease, Medical Xpress reports. More than 10 percent of the general population has the ApoE4 gene variant, which increases the likelihood that they will develop Alzheimer's disease. About two in three people with Alzheimer's have that variant. Previous research has found that the ApoE4 variant lowers levels of SirT1, which promotes the health of brain cells. Increasing levels of SirT1 in those predisposed to or with the disease, researchers have hypothesized, may delay the onset of symptoms and the buildup of a toxic protein known as tau. This results in improved cognition in Alzheimer's patients. Researchers at UCLA's Drug Discovery Lab first identified A03 while screening a large library of drug compounds for their ability to increase levels of SirT1 in the presence of ApoE4. When they treated the ApoE4 model mice with A03 for 56 days, they observed increased levels of SirT1 in the hippocampi of mice—a key area of the brain affected in Alzheimer's. The mice also showed improvement on memory tests. An estimated 5.7 million Americans have Alzheimer's disease and there is currently no cure or effective treatment to stop its progression. The team is conducting further research on A03 to evaluate its potential for clinical testing in Alzheimer's disease. The lab is also developing similar compounds that more effectively increase SirT1 levels in the brain, and these efforts could lead to new drugs to treat the disease. The study appears online in the journal Scientific Reports. Top stories Authorities said a total of 192 Azerbaijani troops were killed and 511 were wounded during Azerbaijan’s offensive. In 2023, the Azerbaijani government will increase the country’s defense budget by more than 1.1 billion manats ($650 million). The bill, published on Monday, is designed to "eliminate the shortcomings of an unreasonably broad interpretation of the key concept of "compatriot". The earthquake caused a temporary blackout, damaged many buildings and closed a number of rural roads. Partner news | Government reveals details from Pashinyan’s meeting in border village Prime Minister Nikol Pashinyan has met with a group of residents of a border village in Armenia’s northern Tavush province Narek Manasyan wins European Boxing Championships silver for Armenia Armenia’s Narek Manasyan (92kg) won Armenia’s second silver medal at the European Boxing Championships 2024 on April 28. Blinken urges Azerbaijan to continue negotiations with Armenia Secretary of State Antony J. Blinken has urged Azerbaijani President Ilham Aliyev to continue negotiations with Armenia. Pashinyan, Blinken talk Armenia-U.S. ties over the phone Prime Minister Nikol Pashinyan had a phone conversation with US Secretary of State Antony Blinken on April 28, Pashinyan’s office reports. |