New peptides improve memory in mice with Alzheimer’s: studySeptember 18, 2019 - 12:26 AMT PanARMENIAN.Net - Alzheimer’s disease (AD) affects over 44 million people the world over. But now, neurologist Jack Jhamandas and his team have found two short peptides which, on daily injection into mice with symptoms of AD for just five weeks, led to a significant improvement, says News Medical. Not only did they have better memory, but they showed a reduction in the accumulation of beta-amyloid, the harmful protein that characterizes the condition, and lower levels of the markers of brain inflammation. Beta-amyloid accumulation may predate the clinical features of AD by 15-25 years. Thus many researchers have tried to reduce amyloid levels either by increasing the rate at which it is removed from the brain or by blocking its formation via enzyme inhibition, but without success. Many such projects have found brain receptors through which beta-amyloid appears to act, such as p75NTR receptor, or SCARA1/2, but none which block all three routes of brain damage: loss of neurons, inflammation, and vascular damage. The amylin receptor (AMY) appears to fulfil this criterion, being found abundantly on neurons, blood vessels, and inflammatory brain cells called microglia. Top stories Authorities said a total of 192 Azerbaijani troops were killed and 511 were wounded during Azerbaijan’s offensive. In 2023, the Azerbaijani government will increase the country’s defense budget by more than 1.1 billion manats ($650 million). The bill, published on Monday, is designed to "eliminate the shortcomings of an unreasonably broad interpretation of the key concept of "compatriot". The earthquake caused a temporary blackout, damaged many buildings and closed a number of rural roads. Partner news | Czech-Armenian military cooperation discussed in Yerevan A delegation led by the Director General for the Industrial Cooperation Division of the Ministry of Defence of the Czech Republic visited Armenia. U.S. welcomes efforts to define Armenia-Azerbaijan border The United States welcomes efforts to define the border between Armenia and Azerbaijan, says Vedant Patel. Biden honors resilience of Armenian people on April 24 U.S. President Joe Biden has issued a statement on the 109th anniversary of the Armenian Genocide. Ex-Karabakh leader moved to solitary confinement cell in Baku, his son says David Vardanyan is the son of former Karabakh leader Ruben Vardanyan who who is currently imprisoned in Azerbaijan. |