Mice may offer clues to scarless healing

PanARMENIAN.Net - Mice with brittle skin, which tears off in order to escape predators, may offer clues to healing wounds without scarring, according to U.S. researchers.

Some African spiny mice lost up to 60% of the skin from their backs, says the study published in the journal Nature, BBC News reports.

Unlike wounds in other mammals, the skin then rapidly healed and regrew hairs rather than forming a scar.

Scientists want to figure out how the healing takes place and if it could apply to people.

Salamanders, some of which can regrow entire limbs, are famed for their regenerative abilities. It has made them the focus of many researchers hoping to figure out how to produce the same effect in people.

Mammals, however, have very limited ability to regrow lost organs. Normally a scar forms to seal the wound.

"This study shows that mammals as a group may in fact have higher regenerative abilities than they are given credit for," said Dr Ashley Seifert from the University of Florida.

As well as rapid skin healing, the mice were also able to heal large circular holes punched in their ears - they regenerated hair follicles, sweat glands and cartilage.

Tests showed the mice produced a "regeneration hub" known as a blastema in order to repair the injury. It is this bundle of stem cells that is also used by the salamander to rebuild missing body parts.

Commenting on the study, Elly Tanaka, from the Technische University Dresden, said: "These studies suggest that the pathways leading to regeneration, at least of the skin, that are normally associated with amphibians are also accessible in mammals."

She added that harnessing the process "in a controlled manner in other wound situations may help to promote scarless healing".