New cancer vaccine yields promising results in miceSeptember 10, 2018 - 17:24 AMT PanARMENIAN.Net - Researchers from the Scripps Research Institute in San Diego, CA, recently worked with experts from other institutions to develop a vaccine that would be effective against melanoma (a type of skin cancer) when administered in conjunction with other therapies, Medical News Today reports. According to Prof. Dale Boger, who co-led the research with Nobel laureate Bruce Beutler, "This co-therapy produced a complete response — a curative response — in the treatment of melanoma." These promising results are reported in a study paper now published in the journal PNAS. The researchers tested three different therapy options in a mouse model of aggressive melanoma. All of the mice received a type of cancer immunotherapy known as anti-PD-L1, but in addition to this, they also received different vaccine variants. Prof. Boger and team split the mice into three groups: one group had the cancer vaccine, another group had the vaccine plus a molecule called Diprovocim, and the third group had the cancer vaccine and another adjuvant: a chemical known as alum. Diprovocim is an adjuvant compound that boosts therapy by reinforcing the immune response. This compound is particularly attractive to researchers developing new therapies, because it is easy to synthesize and modify. The researchers found that the eight mice that received the vaccine plus Diprovocim treatment in addition to the anti-PD-L1 therapy had a 100 percent survival rate over 54 days. In comparison, the rodents that received the immunotherapy plus the vaccine only did not survive. Those that received anti-PD-L1 plus the vaccine with alum saw a 25 percent survival rate over the same period. "It was exciting to see the vaccine working simultaneously with a cancer immunotherapy like anti-PD-L1," Prof. Boger says. Top stories Authorities said a total of 192 Azerbaijani troops were killed and 511 were wounded during Azerbaijan’s offensive. In 2023, the Azerbaijani government will increase the country’s defense budget by more than 1.1 billion manats ($650 million). The bill, published on Monday, is designed to "eliminate the shortcomings of an unreasonably broad interpretation of the key concept of "compatriot". The earthquake caused a temporary blackout, damaged many buildings and closed a number of rural roads. Partner news | Scholz hopes Armenia-Azerbaijan peace treaty will be signed this year German Chancellor Olaf Scholz hopes that a peace treaty between Armenia and Azerbaijan will be signed this year. Ucom equips four bus stops in Ijevan with free Wi-Fi Ucom now provides free Wi-Fi coverage in smart bus stops in four communities of Ijevan. Armenia, Russia discuss life extension of Metsamor nuclear plant Issues regarding the extension of life of the 2nd power unit of the Armenian Nuclear Power Plant were discussed in Yerevan. Armenians stage more campaigns against territorial concessions to Azerbaijan Protesters blocked more roads across Armenia on Friday, April 26 in continuing attempts to scuttle territorial concessions to Azerbaijan. |