Depression treatment regimens for some: studyApril 26, 2019 - 15:42 AMT PanARMENIAN.Net - A new study identifies two potential medication tweaks for certain subgroups of patients with treatment-resistant major depressive disorder. Researchers published their findings online in The American Journal of Psychiatry. “Almost two-thirds of patients with major depressive disorder do not achieve remission with initial treatments,” researchers wrote. “Thus, identifying and providing effective, feasible, and safe ‘next-step’ treatments are clinical imperatives.” The suggestions are based on outcomes from the US Department of Veterans Affairs Augmentation and Switching Treatments for Improving Depression Outcomes (VAST-D) study. The multisite, randomized, single-blind trial included 1522 patients, most of whom were white and older, who had an inadequate response to at least one course of antidepressant treatment. Over 12 weeks, participants received 1 of 3 possible next-step treatments: switching to sustained-release bupropion; combining sustained-release bupropion with their current medication; or augmenting their current medication with the antipsychotic aripiprazole, In patients older than 65, researchers found augmenting with aripiprazole to be more effective in easing depressive symptoms than switching to or adding bupropion. Meanwhile, in patients with severe hypomanic symptoms, either augmenting with aripiprazole or combining their current medication with bupropion was more effective than switching to bupropion. The study also found remission was more likely in patients who worked, who had less severe or chronic depression, experienced less anxiety, did not have symptoms of complicated grief, did not experience childhood adversity, and who had a better quality of life and positive mental health. “If replicated, these preliminary findings could help clinicians determine which patients with depression requiring next-step treatment will benefit most from a specific augmentation, combination, or switching strategy,” researchers wrote. Related links: Top stories Authorities said a total of 192 Azerbaijani troops were killed and 511 were wounded during Azerbaijan’s offensive. In 2023, the Azerbaijani government will increase the country’s defense budget by more than 1.1 billion manats ($650 million). The bill, published on Monday, is designed to "eliminate the shortcomings of an unreasonably broad interpretation of the key concept of "compatriot". The earthquake caused a temporary blackout, damaged many buildings and closed a number of rural roads. Partner news | Scholz hopes Armenia-Azerbaijan peace treaty will be signed this year German Chancellor Olaf Scholz hopes that a peace treaty between Armenia and Azerbaijan will be signed this year. Ucom equips four bus stops in Ijevan with free Wi-Fi Ucom now provides free Wi-Fi coverage in smart bus stops in four communities of Ijevan. Armenia, Russia discuss life extension of Metsamor nuclear plant Issues regarding the extension of life of the 2nd power unit of the Armenian Nuclear Power Plant were discussed in Yerevan. Armenians stage more campaigns against territorial concessions to Azerbaijan Protesters blocked more roads across Armenia on Friday, April 26 in continuing attempts to scuttle territorial concessions to Azerbaijan. |