New compound boosts chemo, prevents treatment resistance: studyJune 10, 2019 - 13:40 AMT PanARMENIAN.Net - Researchers may have found a way to stop cancer cells from defending themselves against chemotherapy. In a new mouse study, blocking a DNA repair pathway prevented cancer cells from surviving or becoming resistant to treatment. Graham Walker, the American Cancer Society Research Professor of Biology at the Massachusetts Institute of Technology (MIT) in Cambridge, is one of the senior authors of the new paper. In his previous research, Prof. Walker studied a DNA repair process that cancer cells rely on to avoid the damage of chemotherapy. This process is called translesion synthesis (TLS). As the researchers explain, healthy cells can normally repair DNA by accurately removing DNA damage. However, when cells become cancerous, they can no longer rely on this normal repair system. Instead, they use TLS, which is less accurate. Specifically, TLS uses specialized TLS DNA polymerases. Polymerases are enzymes that can make copies of DNA. Normal DNA polymerases copy DNA accurately, but TLS DNA polymerases replicate damaged DNA in a less accurate fashion. Top stories Authorities said a total of 192 Azerbaijani troops were killed and 511 were wounded during Azerbaijan’s offensive. In 2023, the Azerbaijani government will increase the country’s defense budget by more than 1.1 billion manats ($650 million). The bill, published on Monday, is designed to "eliminate the shortcomings of an unreasonably broad interpretation of the key concept of "compatriot". The earthquake caused a temporary blackout, damaged many buildings and closed a number of rural roads. Partner news | Cyprus parliament honors Armenian genocide victims Acting House President Zacharias Koulias noted that April 24 marks the “black anniversary” of the Armenian genocide. Armenia PM, France envoy discuss regional matters Issues related to the consistent development of Armenia-France cooperation were discussed. Azerbaijan razes historic Armenian church to ground Azerbaijan has demolished the historic Armenian Church of St. John the Baptist (known as Kanach Zham). Russia to begin assessing migrant workers' speaking skills Rosobrnadzor is planning to change the Russian language exam for migrant workers and include an assessment of speaking skills |