// IP Marketing video - START// IP Marketing video - END

New compound boosts chemo, prevents treatment resistance: study

New compound boosts chemo, prevents treatment resistance: study

PanARMENIAN.Net - Researchers may have found a way to stop cancer cells from defending themselves against chemotherapy. In a new mouse study, blocking a DNA repair pathway prevented cancer cells from surviving or becoming resistant to treatment.

Graham Walker, the American Cancer Society Research Professor of Biology at the Massachusetts Institute of Technology (MIT) in Cambridge, is one of the senior authors of the new paper.

In his previous research, Prof. Walker studied a DNA repair process that cancer cells rely on to avoid the damage of chemotherapy. This process is called translesion synthesis (TLS).

As the researchers explain, healthy cells can normally repair DNA by accurately removing DNA damage.

However, when cells become cancerous, they can no longer rely on this normal repair system. Instead, they use TLS, which is less accurate.

Specifically, TLS uses specialized TLS DNA polymerases. Polymerases are enzymes that can make copies of DNA. Normal DNA polymerases copy DNA accurately, but TLS DNA polymerases replicate damaged DNA in a less accurate fashion.

 Top stories
On land where once stood a cherished church that Sara Corning may have attended, a statue of her now stands.
The integration program initialed by the countries in early September is designed for a year and a half.
Work will be performed in Alexandria, Virginia and Azerbaijan, and is expected to be completed in September 2020.
The exit polls only showed results for seats assigned by party lists, which represent half of the 450-member parliament.
Partner news