Drug that targets body clock could prevent heart attack damage

PanARMENIAN.Net - A preclinical study in mice has tested a new method that could prevent the scarring that occurs after a heart attack and thus prevent heart failure. The researchers have used a drug to target aspects of the body clock that trigger harmful immune responses.

In this medical emergency, the blood flow to the heart becomes obstructed, stopping the organ from functioning normally and damaging some of its muscle tissue, Medical News Today says.

After a heart attack, as the heart tissue begins to heal, scar tissue forms and is unable to contract and relax as well as healthy tissue.

With time, this may lead to heart failure, in which the heart becomes unable to pump blood effectively.

While various treatments can help individuals with heart failure manage their condition, there is no cure that can reverse it. But what if doctors were able to prevent scar tissue from forming after a heart attack and thus make heart failure less likely?

This is precisely what a team of researchers from the University of Guelph, in Ontario, Canada, are working toward. In a preclinical study in mouse models, the research team has tested a new method that aims to prevent the formation of scar tissue in the heart.

In a study paper that appeared today, in Nature Communications Biology, Prof. Tami Martino and Cristine Reitz, a doctoral researcher at Guelph, explain that they have used a research drug called SR9009 to target aspects of the circadian clock, or body clock.

This "clock" regulates the body's automatic functions, such as breathing, as well as other more subtle mechanisms, including some immune system responses. When it comes to heart health, circadian mechanisms control, among other things, the ways in which this organ responds to damage and repairs itself.