High-cholesterol diet may increase risk of colon cancer, science saysJanuary 27, 2018 - 11:53 AMT PanARMENIAN.Net - People eating a high- cholesterol diet are at an increased risk of developing colon cancer, a study warns, according to the Deccan Chrinicle. Scientists discovered that boosting mices cholesterol levels spurred intestinal stem cells to divide more quickly, enabling tumours to form 100 times faster. The study, published in the journal Cell Stem Cell, has identified a molecular pathway that could serve as a new drug target for colon cancer treatment. "We were excited to find that cholesterol influences the growth of stem cells in the intestines, which in turn accelerates the rate of tumour formation by more than 100- fold," said Peter Tontonoz, from the University of California, Los Angeles in the US. "While the connection between dietary cholesterol and colon cancer is well established, no one has previously explained the mechanism behind it," Tontonoz said. The scientists increased cholesterol in the intestinal stem cells in some of the mice by introducing more of the substance into their diets. In others, the researchers altered a gene that regulates phospholipids, the primary type of fat in cell membranes, which spurred the cells into producing more cholesterol on their own. The stem cells ability to multiply increased in both groups. As the animals cholesterol levels rose, their cells divided more rapidly, causing the tissue lining their guts to expand and their intestines to lengthen. These changes significantly sped up the rate of tumour formation in their colons. Top stories Authorities said a total of 192 Azerbaijani troops were killed and 511 were wounded during Azerbaijan’s offensive. In 2023, the Azerbaijani government will increase the country’s defense budget by more than 1.1 billion manats ($650 million). The bill, published on Monday, is designed to "eliminate the shortcomings of an unreasonably broad interpretation of the key concept of "compatriot". The earthquake caused a temporary blackout, damaged many buildings and closed a number of rural roads. Partner news | Government reveals details from Pashinyan’s meeting in border village Prime Minister Nikol Pashinyan has met with a group of residents of a border village in Armenia’s northern Tavush province Narek Manasyan wins European Boxing Championships silver for Armenia Armenia’s Narek Manasyan (92kg) won Armenia’s second silver medal at the European Boxing Championships 2024 on April 28. Blinken urges Azerbaijan to continue negotiations with Armenia Secretary of State Antony J. Blinken has urged Azerbaijani President Ilham Aliyev to continue negotiations with Armenia. Pashinyan, Blinken talk Armenia-U.S. ties over the phone Prime Minister Nikol Pashinyan had a phone conversation with US Secretary of State Antony Blinken on April 28, Pashinyan’s office reports. |