Neural link between depression and sleep problems identified

Neural link between depression and sleep problems identified

PanARMENIAN.Net - The neural link between depression and sleep problems has been identified for the first time in a new study by researchers at the University of Warwick (UK) and Fudan University (China), News Medical reports.

Professor Jianfeng Feng and Professor Edmund Rolls from Warwick's Department of Computer Science, with Dr. Wei Cheng from Fudan University, found functional connectivity between the areas of the brain associated with short-term memory, self, and negative emotions - causing sufferers to dwell on bad thoughts and leading to a poor quality of sleep.

This research could lead to better sleep quality for people with depression, and opens up the possibility of new targeted treatments.

Analysing data from around 10,000 people, the researchers examined the neural mechanisms underlying the relation between depression and quality of sleep.

In the brains of those living with depressive problems, they discovered a strong connection between the dorsolateral prefrontal cortex (associated with short-term memory), the precuneus (associated with the self) and the lateral orbitofrontal cortex (associated with negative emotion).

The analysis showed that these functional connectivities underlie the relation between depressive problems and sleep quality.

The researchers conclude that increased functional connectivity between these brain regions provides a neural basis for how depression is related to poor sleep quality.

Professor Jianfeng Feng, from the University of Warwick's Department of Computer Science, said:

"The understanding that we develop here is consistent with areas of the brain involved in short-term memory (the dorsolateral prefrontal cortex), the self (precuneus), and negative emotion (the lateral orbitofrontal cortex) being highly connected in depression, and that this results in increased ruminating thoughts which are at least part of the mechanism that impairs sleep quality."

Professor Edmund Rolls also commented: "This study may also have implications for a deeper understanding of depression. This important cross-validation with participants from the USA provides support for the theory that the lateral orbitofrontal cortex is a key brain area that might be targeted in the search for treatments for depression."

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